Artlabeling Activity Blood Vessels of the Thoracic Cavity Pearson Diagram
6.3 Bone Structure
Learning Objectives
By the end of this section, you will be able to:
Describe the microscopic and gross anatomical structures of bones
- Identify the gross anatomical features of a bone
- Describe the histology of bone tissue, including the function of bone cells and matrix
- Compare and contrast compact and spongy bone
- Identify the structures that compose meaty and spongy os
- Depict how bones are nourished and innervated
- function?
Os tissue (osseous tissue) differs profoundly from other tissues in the trunk. Bone is hard and many of its functions depend on that characteristic hardness. Later discussions in this affiliate volition show that bone is also dynamic in that its shape adjusts to accommodate stresses. This section volition examine the gross beefcake of bone kickoff and then move on to its histology.
Gross Beefcake of Basic
A long bone has two main regions: the diaphysis and the epiphysis (Figure half dozen.3.one). The diaphysis is the hollow, tubular shaft that runs between the proximal and distal ends of the bone. Inside the diaphysis is the medullary cavity, which is filled with yellowish bone marrow in an adult. The outer walls of the diaphysis ( cortex, cortical bone)are composed of dense and hard compact bone, a form of osseous tissue.
The wider section at each end of the bone is called the epiphysis (plural = epiphyses), which is filled internally with spongy os, another type of osseous tissue. Cerise os marrow fills the spaces between the spongy bone in some long basic. Each epiphysis meets the diaphysis at the metaphysis.During growth, the metaphysis contains the epiphyseal plate, the site of long os elongation described afterward in the chapter. When the os stops growing in early on adulthood (approximately 18–21 years), the epiphyseal plate becomes an epiphyseal line seen in the figure.
Lining the inside of the bone adjacent to the medullary cavity is a layer of os cells called the endosteum (endo- = "inside"; osteo- = "os"). These os cells (described later) cause the os to abound, repair, and remodel throughout life. On the outside of bones there is another layer of cells that abound, repair and remodel bone besides. These cells are part of the outer double layered construction called the periosteum (peri– = "around" or "surrounding"). The cellular layer is adjacent to the cortical bone and is covered by an outer gristly layer of dumbo irregular connective tissue (see Figure 6.3.4a). The periosteum also contains blood vessels, nerves, and lymphatic vessels that attend compact os. Tendons and ligaments adhere to basic at the periosteum. The periosteum covers the entire outer surface except where the epiphyses meet other bones to form joints (Figure half dozen.3.2). In this region, the epiphyses are covered with articular cartilage, a sparse layer of hyaline cartilage that reduces friction and acts as a daze absorber.
Apartment bones, like those of the attic, consist of a layer of diploƫ (spongy bone), covered on either side by a layer of compact bone (Figure 6.three.3). The ii layers of compact bone and the interior spongy bone piece of work together to protect the internal organs. If the outer layer of a cranial bone fractures, the brain is all the same protected by the intact inner layer.
Osseous Tissue: Os Matrix and Cells
Bone Cells
Although bone cells compose less than 2% of the os mass, they are crucial to the function of bones. Four types of cells are constitute within bone tissue: osteoblasts, osteocytes, osteogenic cells, and osteoclasts (Effigy vi.three.5).
The osteoblast is the bone cell responsible for forming new bone and is found in the growing portions of bone, including the endosteum and the cellular layer of the periosteum. Osteoblasts, which do non divide, synthesize and secrete the collagen matrix and other proteins. As the secreted matrix surrounding the osteoblast calcifies, the osteoblast become trapped within information technology; as a result, it changes in construction and becomes an osteocyte, the principal cell of mature bone and the most common type of bone cell. Each osteocyte is located in a small-scale crenel in the bone tissue called a lacuna (lacunae for plural). Osteocytes maintain the mineral concentration of the matrix via the secretion of enzymes. Like osteoblasts, osteocytes lack mitotic activeness. They can communicate with each other and receive nutrients via long cytoplasmic processes that extend through canaliculi (singular = canaliculus), channels within the bone matrix. Osteocytes are connected to one another inside the canaliculi via gap junctions.
If osteoblasts and osteocytes are incapable of mitosis, then how are they replenished when old ones die? The answer lies in the properties of a tertiary category of bone cells—the osteogenic (osteoprogenitor) prison cell. These osteogenic cells are undifferentiated with loftier mitotic activity and they are the only bone cells that divide. Immature osteogenic cells are found in the cellular layer of the periosteum and the endosteum. They differentiate and develop into osteoblasts.
The dynamic nature of bone ways that new tissue is constantly formed, and onetime, injured, or unnecessary bone is dissolved for repair or for calcium release. The cells responsible for bone resorption, or breakdown, are the osteoclasts. These multinucleated cells originate from monocytes and macrophages, 2 types of white blood cells, non from osteogenic cells. Osteoclasts are continually breaking down quondam bone while osteoblasts are continually forming new os. The ongoing balance between osteoblasts and osteoclasts is responsible for the abiding but subtle reshaping of bone. Table 6.three reviews the bone cells, their functions, and locations.
Bone Cells (Table 6.3) | ||
---|---|---|
Cell type | Function | Location |
Osteogenic cells | Develop into osteoblasts | Endosteum, cellular layer of the periosteum |
Osteoblasts | Os formation | Endosteum, cellular layer of the periosteum, growing portions of bone |
Osteocytes | Maintain mineral concentration of matrix | Entrapped in matrix |
Osteoclasts | Bone resorption | Endosteum, cellular layer of the periosteum, at sites of old, injured, or unneeded bone |
Compact and Spongy Bone
Well-nigh bones comprise meaty and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function. Although compact and spongy os are fabricated of the same matrix materials and cells, they are unlike in how they are organized. Compact bone is dumbo and so that it can withstand compressive forces, while spongy os (also called cancellous bone) has open spaces and is supportive, but too lightweight and can exist readily remodeled to adjust irresolute body needs.
Meaty Bone
Compact bone is the denser, stronger of the ii types of osseous tissue (Figure 6.3.6). It makes up the outer cortex of all bones and is in firsthand contact with the periosteum. In long bones, as you movement from the outer cortical compact bone to the inner medullary crenel, the bone transitions to spongy bone.
If you lot look at meaty os under the microscope, you lot will discover a highly organized arrangement of concentric circles that look similar tree trunks. Each grouping of concentric circles (each "tree") makes upwards the microscopic structural unit of compact bone called an osteon (this is also called a Haversian system). Each band of the osteon is made of collagen and calcified matrix and is chosen a lamella (plural = lamellae). The collagen fibers of adjacent lamallae run at perpendicular angles to each other, assuasive osteons to resist twisting forces in multiple directions (see figure half-dozen.34a). Running down the center of each osteon is the central culvert, or Haversian canal, which contains claret vessels, nerves, and lymphatic vessels. These vessels and fretfulness branch off at right angles through a perforating culvert, also known every bit Volkmann'due south canals, to extend to the periosteum and endosteum. The endosteum also lines each primal canal, allowing osteons to be removed, remodeled and rebuilt over fourth dimension.
The osteocytes are trapped within their lacuane, constitute at the borders of adjacent lamellae. As described earlier, canaliculi connect with the canaliculi of other lacunae and eventually with the cardinal canal. This system allows nutrients to exist transported to the osteocytes and wastes to be removed from them despite the impervious calcified matrix.
Spongy (Cancellous) Bone
Like compact bone, spongy bone, also known as cancellous bone, contains osteocytes housed in lacunae, but they are non bundled in concentric circles. Instead, the lacunae and osteocytes are found in a lattice-similar network of matrix spikes called trabeculae (singular = trabecula) (Effigy vi.3.8). The trabeculae are covered by the endosteum, which tin can readily remodel them. The trabeculae may announced to be a random network, but each trabecula forms along lines of stress to direct forces out to the more solid compact bone providing force to the bone. Spongy bone provides rest to the dense and heavy compact os by making bones lighter so that muscles tin move them more hands. In addition, the spaces in some spongy bones contain red os marrow, protected by the trabeculae, where hematopoiesis occurs.
Crumbling and the…Skeletal System: Paget's Disease
Paget's illness normally occurs in adults over historic period forty. Information technology is a disorder of the bone remodeling procedure that begins with overactive osteoclasts. This ways more os is resorbed than is laid down. The osteoblasts try to compensate but the new bone they lay down is weak and brittle and therefore prone to fracture.
While some people with Paget'due south disease accept no symptoms, others experience pain, os fractures, and bone deformities (Figure 6.3.9). Bones of the pelvis, skull, spine, and legs are the almost unremarkably affected. When occurring in the skull, Paget'south illness can cause headaches and hearing loss.
What causes the osteoclasts to get overactive? The respond is still unknown, but hereditary factors seem to play a role. Some scientists believe Paget'south disease is due to an as-yet-unidentified virus.
Paget'due south disease is diagnosed via imaging studies and lab tests. X-rays may show bone deformities or areas of bone resorption. Bone scans are also useful. In these studies, a dye containing a radioactive ion is injected into the body. Areas of bone resorption accept an affinity for the ion, and so they will lite up on the scan if the ions are absorbed. In addition, claret levels of an enzyme chosen alkaline phosphatase are typically elevated in people with Paget's disease. Bisphosphonates, drugs that decrease the action of osteoclasts, are oftentimes used in the handling of Paget's disease.
Blood and Nerve Supply
The spongy bone and medullary cavity receive nourishment from arteries that pass through the compact bone. The arteries enter through the nutrient foramen (plural = foramina), minor openings in the diaphysis (Figure half-dozen.three.10). The osteocytes in spongy bone are nourished by blood vessels of the periosteum that penetrate spongy bone and blood that circulates in the marrow cavities. As the blood passes through the marrow cavities, it is collected by veins, which then pass out of the bone through the foramina.
In improver to the claret vessels, nerves follow the same paths into the bone where they tend to concentrate in the more metabolically active regions of the bone. The nerves sense hurting, and it appears the nerves as well play roles in regulating claret supplies and in bone growth, hence their concentrations in metabolically active sites of the bone.
External Website
Watch this video to see the microscopic features of a bone.
Chapter Review
A hollow medullary crenel filled with xanthous marrow runs the length of the diaphysis of a long bone. The walls of the diaphysis are compact os. The epiphyses, which are wider sections at each cease of a long os, are filled with spongy bone and carmine marrow. The epiphyseal plate, a layer of hyaline cartilage, is replaced by osseous tissue as the organ grows in length. The medullary crenel has a delicate membranous lining called the endosteum. The outer surface of bone, except in regions covered with articular cartilage, is covered with a fibrous membrane chosen the periosteum. Apartment bones consist of ii layers of compact bone surrounding a layer of spongy bone. Bone markings depend on the function and location of bones. Articulations are places where two basic encounter. Projections stick out from the surface of the os and provide attachment points for tendons and ligaments. Holes are openings or depressions in the bones.
Bone matrix consists of collagen fibers and organic footing substance, primarily hydroxyapatite formed from calcium salts. Osteogenic cells develop into osteoblasts. Osteoblasts are cells that make new bone. They become osteocytes, the cells of mature os, when they get trapped in the matrix. Osteoclasts engage in os resorption. Compact bone is dumbo and equanimous of osteons, while spongy bone is less dumbo and fabricated up of trabeculae. Claret vessels and nerves enter the bone through the nutrient foramina to nourish and innervate basic.
Review Questions
Critical Thinking Questions
one. If the articular cartilage at the end of ane of your long bones were to degenerate, what symptoms do y'all think y'all would feel? Why?
2. In what ways is the structural makeup of compact and spongy bone well suited to their respective functions?
Glossary
- articular cartilage
- sparse layer of cartilage covering an epiphysis; reduces friction and acts as a daze absorber
- articulation
- where two bone surfaces meet
- canaliculi
- (atypical = canaliculus) channels within the bone matrix that house ane of an osteocyte's many cytoplasmic extensions that it uses to communicate and receive nutrients
- central canal
- longitudinal channel in the middle of each osteon; contains blood vessels, nerves, and lymphatic vessels; also known equally the Haversian canal
- meaty bone
- dense osseous tissue that can withstand compressive forces
- diaphysis
- tubular shaft that runs between the proximal and distal ends of a long bone
- diploƫ
- layer of spongy bone, that is sandwiched between two the layers of compact bone constitute in apartment basic
- endosteum
- delicate membranous lining of a bone'south medullary cavity
- epiphyseal plate
- (also, growth plate) canvas of hyaline cartilage in the metaphysis of an immature bone; replaced by bone tissue as the organ grows in length
- epiphysis
- broad section at each end of a long bone; filled with spongy bone and red marrow
- pigsty
- opening or depression in a bone
- lacunae
- (atypical = lacuna) spaces in a os that house an osteocyte
- medullary cavity
- hollow region of the diaphysis; filled with xanthous marrow
- nutrient foramen
- small opening in the middle of the external surface of the diaphysis, through which an avenue enters the bone to provide nourishment
- osteoblast
- jail cell responsible for forming new bone
- osteoclast
- cell responsible for resorbing bone
- osteocyte
- primary jail cell in mature bone; responsible for maintaining the matrix
- osteogenic prison cell
- undifferentiated cell with loftier mitotic action; the only bone cells that dissever; they differentiate and develop into osteoblasts
- osteon
- (likewise, Haversian system) basic structural unit of measurement of compact bone; made of concentric layers of calcified matrix
- perforating canal
- (also, Volkmann's culvert) channel that branches off from the central canal and houses vessels and fretfulness that extend to the periosteum and endosteum
- periosteum
- fibrous membrane covering the outer surface of bone and continuous with ligaments
- projection
- bone markings where part of the surface sticks out above the rest of the surface, where tendons and ligaments attach
- spongy bone
- (too, cancellous os) trabeculated osseous tissue that supports shifts in weight distribution
- trabeculae
- (atypical = trabecula) spikes or sections of the lattice-like matrix in spongy os
Solutions
Answers for Critical Thinking Questions
- If the articular cartilage at the end of 1 of your long bones were to deteriorate, which is actually what happens in osteoarthritis, you would experience joint pain at the end of that os and limitation of motion at that joint because there would be no cartilage to reduce friction between next bones and there would be no cartilage to act equally a shock absorber.
- The densely packed concentric rings of matrix in meaty bone are ideal for resisting compressive forces, which is the function of compact bone. The open up spaces of the trabeculated network of spongy bone allow spongy bone to support shifts in weight distribution, which is the role of spongy bone.
Bone Markings
Define and list examples of os markings
The surface features of bones vary considerably, depending on the role and location in the torso. Table 6.2 describes the os markings, which are illustrated in (Figure 6.3.4). There are 3 full general classes of os markings: (1) articulations, (ii) projections, and (3) holes. As the name implies, an articulation is where two os surfaces come up together (articulus = "joint"). These surfaces tend to conform to 1 another, such as one being rounded and the other cupped, to facilitate the part of the articulation. A project is an area of a bone that projects to a higher place the surface of the bone. These are the attachment points for tendons and ligaments. In general, their size and shape is an indication of the forces exerted through the attachment to the bone. A hole is an opening or groove in the os that allows blood vessels and nerves to enter the bone. Every bit with the other markings, their size and shape reflect the size of the vessels and nerves that penetrate the bone at these points.
Bone Markings (Tabular array half dozen.2) | ||
---|---|---|
Marking | Clarification | Instance |
Articulations | Where two basic meet | Knee |
Head | Prominent rounded surface | Head of femur |
Facet | Apartment surface | Vertebrae |
Condyle | Rounded surface | Occipital condyles |
Projections | Raised markings | Spinous procedure of the vertebrae |
Protuberance | Protruding | Chin |
Process | Prominence characteristic | Transverse process of vertebra |
Spine | Sharp process | Ischial spine |
Tubercle | Small, rounded process | Tubercle of humerus |
Tuberosity | Rough surface | Deltoid tuberosity |
Line | Slight, elongated ridge | Temporal lines of the parietal bones |
Crest | Ridge | Iliac crest |
Holes | Holes and depressions | Foramen (holes through which blood vessels can pass through) |
Fossa | Elongated basin | Mandibular fossa |
Fovea | Small pit | Fovea capitis on the caput of the femur |
Sulcus | Groove | Sigmoid sulcus of the temporal bones |
Canal | Passage in bone | Auditory culvert |
Cleft | Slit through bone | Auricular crevice |
Foramen | Hole through os | Foramen magnum in the occipital bone |
Meatus | Opening into culvert | External auditory meatus |
Sinus | Air-filled space in bone | Nasal sinus |
Source: https://open.oregonstate.education/aandp/chapter/6-3-bone-structure/